In Press

Frazier JA, Bregman HR, Jackson JA. Atypical Antipsychotics in the Treatment of Early Onset Bipolar Disorder. In: Geller B, Delbello M (Eds). Treatment of Bipolar Disorder in Children and Adolescents (in press).

Journal articles - Treatment

Frazier JA, McClellan J, Findling RL, Vitiello B, Anderson R, et al. Treatment of early-onset schizophrenia spectrum disorders (TEOSS): demographic and clinical characteristics. J Am Acad Child Adolesc Psychiatry. 2007; 46:979-88

McClellan J, Sikich L, Findling RL, Frazier JA, Vitiello B, et al. Treatment of early-onset schizophrenia spectrum disorders (TEOSS): rationale, design, and methods. J Am Acad Child Adolesc Psychiatry. 2007; 46:969-78.

Findling RL, Frazier JA, Gerbino-Rosen G, Kranzler HN, Kumra S, Kratochvil CJ. Is there a role for clozapine in the treatment of children and adolescents? J Am Acad Child Adolesc Psychiatry. 2007; 46:423-8.

Frazier JA, Gordon CT, McKenna K, Lenane M, Jih D, Rapoport JL. An open trial of clozapine in 11 adolescents with childhood onset schizophrenia. J Am Acad Child Adolesc Psychiatry 1994; 33:658-63.

Kumra S, Frazier JA, Jacobsen LK, McKenna K, Gordon CT, Hamburger S, Smith AK, Albus KE, Alaghband-Rad J, Lenane M, Rapoport JL. Childhood onset schizophrenia: A double blind clozapine trial. Arch Gen Psychiatry 1996; 53:1090-97.

Kumra S, Jacobsen LK, Lenane M, Karp BI, Frazier JA, Smith K, Bedwell J, Lee P, Malanga CJ, Hamburger S, Rapoport JL. Childhood-onset schizophrenia: An open-label study of olanzapine in adolescents. J Am Acad Child Adolesc Psychiatry 1998; 37:377-85.

Frazier JA, Meyer MC, Biederman J, Wozniak J, Wilens T, Spencer T, Kim G, Shapiro S. Risperidone Treatment for juvenile bipolar disorder: A retrospective chart review. J Am Acad Child Adolesc Psychiatry 1999; 38:960-5.

Frazier JA, Biederman J, Tohen M, Feldman PD, Jacobs TG, Toma V, Rater MA, Tarazi RA, Kim GS, Garfield SB, Sohma M, Gonzalez Heydrich J, Risser RC, Nowlin ZM. A prospective open-label treatment trial of olanzapine monotherapy in children and adolescents with bipolar disorder. J Child Adolesc Psychopharmacol 2001; 11:239-50.

Wagner KD, Weller EB, Carlson G, Sachs GA, Biederman J, Frazier JA, Wozniak P, Tracy K, Weller RA, Bowden C. An open-label trial of divalproex in children and adolescents with bipolar disorder. J Am Acad Child Adolesc Psychiatry 2002; 41:1224-30.

Frazier JA, Cohen LG, Jacobsen L, Grothe D, Flood J, Baldessarini RJ, Piscitelli S, Kim G, Rapoport JL. Clozapine pharmacokinetics in children and adolescents with childhood-onset schizophrenia. J Clin Psychopharmacol 2003; 23:87-91.

Ahn M, Frazier JA. Diagnostic and treatment issues in childhood-onset bipolar disorder. Essential Psychopharmacol 2004; 6:25-44.

Hirshberg LM, Chiu S, Frazier JA. Emerging brain-based interventions for children and adolescents: overview and clinical perspective. Child Adolesc Psychiatr Clin N Am 2005; 14:1-19.

Doyle R, Frazier JA, Spencer TJ, Geller D, Biederman J, Wilens T. Donepezil in the treatment of ADHD-like symptoms in youths with Pervasive Developmental Disorder: a case series. J Att Disord 2006; 93:543-9.

Lopez-Larson MP, Frazier JA. Empirical evidence for the use of lithium and anticonvulsants in children with psychiatric disorders. Harv Rev Psychiatry 2006; 14:285-304.

Journal articles - Neuroimaging

Frazier JA, Breeze JL, Papadimitriou G, Kennedy DN, Hodge SM, Moore CM, Howard JD, Rohan ML, Caviness VS, Makris N. White matter abnormalities in children with and at risk for bipolar disorder. Bipolar Disord 2007; 9:799-809.

Frazier JA, Hodge SM, Breeze JL, Giuliano AJ, Terry JE, Moore CM, Kennedy DN, Lopez-Larson MP, et al. Diagnostic and sex effects on limbic volumes in early-onset bipolar disorder and schizophrenia. Schizophr Bull. 2008; 34:37-46.

Ahn MS, Breeze JL, Makris N, Kennedy DN, Hodge SM, Herbert MR, Seidman LJ, Biederman J, Caviness VS, Frazier JA. Anatomic
brain magnetic resonance imaging of the basal ganglia in pediatric bipolar disorder. J Affect Disord. 2007; 104:147-54.

Moore CM, Frazier JA, Glod CA, Breeze JL, Dieterich M, Finn CT, Frederick B, Renshaw PF. Glutamine and glutamate levels in children and adolescents with bipolar disorder: a 4.0-T proton magnetic resonance spectroscopy study of the anterior cingulate cortex. J Am Acad Child Adolesc Psychiatry. 2007; 46:524-34.

Frazier JA, Giedd J, Kaysen D, Albus K, Alaghband-Rad J, Lenane M, Breier A, Rapoport J. Childhood onset schizophrenia: Brain MRI rescan after two years of clozapine maintenance. Am J Psychiatry 1996; 153:564-66.

Jacobsen LK, Giedd JN, Vaituzis AC, Hamburger SD, Rajapakse JC, Frazier JA, Kaysen D, Lenane MC, McKenna K, Gordon CT, Rapoport JL. Temporal lobe morphology in childhood-onset schizophrenia. Am J Psychiatry 1996; 153:355-61.

Frazier JA, Giedd J, Hamburger SD, Albus K, Kaysen D, Vaituzis C, Rajapakse JC, Lenane MC, McKenna K, Jacobsen L, Gordon CT, Breier A, Rapoport JL. Brain anatomic magnetic resonance imaging in childhood onset schizophrenia. Arch Gen Psychiatry 1996; 53:617-24.

Jacobsen LK, Giedd JN, Rajapakse JC, Hamburger SD, Vaituzis AC, Frazier JA, Lenane MC, Rapoport JL. Quantitative magnetic resonance imaging of the corpus callosum in childhood onset schizophrenia. Psychiatry Res 1997; 68:77-86.

Bush G, Frazier JA, Rauch SL, Seidman LJ, Whalen PJ, Jenike MA, Rosen BR, Biederman J. Anterior cingulate cortex dysfunction in attention-deficit/hyperactivity disorder revealed by fMRI and the Counting Stroop. Biol Psychiatry 1999; 45:1542-52.

Karp BI, Garvey M, Jacobsen LK, Frazier JA, Hamburger SD, Bedwell JS, Rapoport JL. Abnormal neurologic maturation in adolescents with early-onset schizophrenia. Am J Psychiatry 2001; 158:118-22.

Breeze JL, Hesdorffer DC, Hong X, Frazier JA, Renshaw PF. Clinical significance of brain white matter hyperintensities in young adults with psychiatric illness. Harv Rev Psychiatry 2003; 11:269-83.

De Fosse L, Hodge SM, Makris N, Kennedy DN, Caviness VS Jr, McGrath L, Steele S, Ziegler DA, Herbert MR, Frazier JA, Tager-Flusberg H, Harris GJ. Language-association cortex asymmetry in autism and specific language impairment. Ann Neurol 2004; 56:757-66.

Frazier JA, Chiu S, Breeze JL, Makris N, Lange N, Kennedy DK, Herbert MK, Bent EK, Koneru VK, Dieterich ME, Hodge SM, Rauch SL, Grant PE, Cohen BM, Seidman LJ, Caviness VS, Biederman J. Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorder. Am J Psychiatry 2005; 162:757-66.

Frazier JA, Ahn MS, DeJong S, Bent EK, Breeze JL, Giuliano AJ. Magnetic resonance imaging studies in early-onset bipolar disorder: a critical review. Harv Rev Psychiatry 2005; 13:125-40.

Frazier JA, Breeze JL, Makris N, Giuliano AS, Herbert MR, Seidman L, Biederman J, Hodge SM, Dieterich ME, Gerstein E, Kennedy DN, Rauch SL, Cohen B, Caviness VS. Cortical grey matter differences identified by structural magnetic resonance imaging in pediatric bipolar disorder. Bipolar Disord 2005; 7:555-69.

O'Brien LM, Ziegler DA, Deutsch CK, Kennedy DN, Goldstein J, Seidman LJ, Hodge SM, Makris N, Caviness VS, Frazier JA, Herbert MR. Adjusting for head size differences in volumetric brain studies: a review of common adjustment factors and statistical methods. Harv Rev Psychiatry.

Journal articles - Case Studies / Other

Jacobsen LK, Hommer DW, Hong WL, Castellanos FX, Frazier JA, Giedd JN, Rapoport JL. Blink rate in childhood-onset schizophrenia: comparison with normal and attention-deficit hyperactivity disorder controls. Biol Psychiatry 1996; 40:1222-9.

Jacobsen LK, Hong WL, Hommer DW, Hamburger SD, Castellanos FX, Frazier JA, Giedd JN, Gordon CT, Karp BI, McKenna K, Rapoport JL. Smooth pursuit eye movements in childhood-onset schizophrenia: comparison with attention-deficit hyperactivity disorder and normal controls. Biol Psychiatry 1996; 40:1144-54.

Zahn TP, Jacobsen LK, Gordon CT, McKenna K, Frazier JA, Rapoport JL. Autonomic nervous system markers of psychopathology in childhood-onset schizophrenia. Arch Gen Psychiatry 1997; 54:904-12.

Jacobsen LK, Frazier JA, Malhotra AK, Karoum F, McKenna K, Gordon CT, Hamburger SD, Lenane MC, Pickar D, Potter WZ, Rapoport JL. Cerebrospinal fluid monoamine metabolites in childhood-onset schizophrenia. Am J Psychiatry 1997; 154:69-74.

Alaghband-Rad J, Hamburger SD, Giedd JN, Frazier JA, Rapoport JL. Childhood-onset schizophrenia: biological markers in relation to clinical characteristics. Am J Psychiatry 1997; 154:64-8.

Frazier JA, Alaghband-Rad J, Jacobsen L, Lenane MC, Hamburger S, Albus K, Smith A, McKenna K, Rapoport JL. Pubertal development and onset of psychosis in childhood onset schizophrenia. Psychiatry Res 1997; 70:1-7.

Wozniak J, Biederman J, Faraone S, Frazier J, Kim J, Millstein R, Gershon J, Thornell A, Cha K, Snyder J. Mania in children with pervasive developmental disorder, revisited. J Am Acad Child Adolesc Psychiatry 1997; 36:1552-60.

Jacobsen LK, Hamburger SD, Van Horn JD, Vaituzis AC, McKenna K, Frazier JA, Gordon CT, Lenane MC, Rapoport JL, Zametkin AJ. Cerebral glucose metabolism in childhood onset schizophrenia. Psychiatry Res 1997; 75:131-44.

Kumra S, Jacobsen LK, Lenane M, Zahn TP, Wiggs E, Alaghband-Rad J, Castellanos FX, Frazier JA, McKenna K, Gordon CT, Smith A, Hamburger S, Rapoport JL. "Multidimensionally impaired disorder": is it a variant of very early-onset schizophrenia? J Am Acad Child Adolesc Psychiatry 1998; 37:91-9.

Zahn TP, Jacobsen LK, Gordon CT, McKenna K, Frazier JA, Rapoport JL. Attention deficits in childhood-onset schizophrenia: reaction time studies. J Abnorm Psychol 1998; 107:97-108.

Coffey BJ, Biederman J, Geller DA, Spencer TJ, Kim GS, Bellordre CA, Frazier JA, Cradock K, Magovcevic M. Distinguishing illness severity from tic severity in children and adolescents with Tourette's disorder. J Am Acad Child Adolesc Psychiatry 2000; 39:556-61.

Frazier JA, Doyle R, Chiu S, Coyle J. Clinical Case Report: Can a child with Asperger's syndrome have comorbid bipolar disorder? Am J Psychiatry 2002; 4:52-8.
Coffey BJ, Biederman J, Geller D, Frazier J, Spencer T, Doyle R, Gianini L, Small A, Frisone DF, Magovcevic M, Stein N, Faraone SV. Reexamining Tic persistence and Tic-associated impairment in Tourette's Disorder: findings from a naturalistic follow-up study. J Nerv Ment Dis. 2004; 192:776-80.

Ahn MS, Sims KB, Frazier JA. Risperidone-induced psychosis and depression in a child with a mitochondrial disorder. J Child Adolesc Psychopharmacol 2005; 15:520-5.

Rappaport N, Frazier JA, Connor D, Mattison R. From zero to a hundred in a split second: understanding aggression in an eight year old student. Harv Rev Psychiatry.

Navalta CP, Goldstein J, Ruegg L, Perna DA, Frazier JA. Integrating treatment and education for mood disorders: an adolescent case report. Clin Child Psychol Psychiatry. 2006; 11:555-68.

Book Chapters

Coffey B, Frazier JA, Chen S. Comorbidity, Tourette's Syndrome and Anxiety Disorders. In: Advances in Neurology. New York: Raven Press, 1992. pp. 96-104.

Frazier JA, Barrett R, Walters A, Feinstein C. Moderate to profound mental retardation. In: Noshpitz J and Alessi NE (Eds.) Handbook of Child and Adolescent Psychiatry. New York: Wiley and Sons, 1997. pp. 397-408.

Frazier JA, Spencer T, Wilens T, Wozniak J, Biederman J. Childhood onset schizophrenia, the prototypic psychotic disorder of childhood. In: Dunner DL, Rosenbaum JF (Eds.) Psychiatry Clinics of North American: Annual of Drug Therapy. Philadelphia: W.B. Saunders Company, 1997. pp. 167-93.

Wilens T, Spencer TJ, Frazier JA, Biederman J. Child and adolescent psychopharmacology. In: Ollendick T, Hersen M (Eds.) Handbook of child psychopathology, 3rd Edition. New York: Plenum Press, 1998. pp. 603-36

Frazier JA. Mental retardation. In: Finberg L (Ed.) Saunders Manual of Pediatric Practice. Philadelphia: W.B. Saunders Company, 1998. pp. 154-6.

Frazier JA. Autism, Asperger's and Schizophrenia. In: Finberg L. (Ed.) Saunders Manual of Pediatric Practice. Philadelphia: W.B. Saunders Company, 1998. pp. 172-4.

Frazier JA. The mentally retarded person. In: Nicoli A (Ed.) The New Harvard Guide to Psychiatry. Cambridge: The Belkap Press, 1999. pp. 660-71.

Abrams A, Frazier JA. Psychopharmacology in children and adolescents. In: Stern T (Ed.) The MGH Board Review Text. New York: McGraw-Hill, 2000. pp. 31-40.

Chiu S, Frazier JA. Autism, Asperger's and Schizophrenia. In: Finberg L and Kleinman RE (Eds.) Saunders Manual of Pediatric Practice. Philadelphia: W.B. Saunders Company, 2002. pp. 191-5.

Chiu S, Frazier JA. Mental retardation. In: Finberg L and Kleinman RE (Eds.) Saunders Manual of Pediatric Practice. Philadelphia: W.B. Saunders Company, 2002. pp. 188-91.

Frazier JA. Agitation and aggression. In: Martin A, Scahill L, Charney D, Leckman J (Eds.) Pediatric Psychopharmacology: Principles and Practice. New York: Oxford University Press, 2003. pp. 671-85.

DeJong S, Frazier JA. Bipolar disorder in children with pervasive developmental disorders. In: Geller B, DelBello M. (Eds.) Child and Early Adolescent Bipolar Disorder. New York: Guilford Publications, 2003. pp. 51-75.

Abrams A, Frazier JA. Psychopharmacology in children and adolescents. In: Stern TA, Herman JB (Eds.) Psychiatry Update and Board Preparation, 2nd Edition. New York: McGraw-Hill Companies, 2004. pp. 33-42.

DeJong S, Giuliano AJ, Frazier JA. Antipsychotic Medications in Child Psychiatry. In: Chang K, Steiner H (Eds.) Handbook of Mental Health Interventions in Children and Adolescents: An Integrated Developmental Approach. New York: Jossey-Bass/Wiley, 2004. pp. 413-464.